Biology and Medicine

Bioengineering can be thought of as the application of engineering principles and techniques to biology and medicine. The scope of the field is broad, ranging from the development of prosthetics and specialized medical devices to the study of cellular chemical production. This case study collection features bioengineering applications in which optimization plays a key role in the analysis and/or solution of the problem.

  • Enzyme Cost Minimization
    The Enzyme Cost Minimization case study describes the optimization of a metabolic network and uses the ECM solver to process the models. The case study includes an interactive demo of the ECM solver.
  • Metabolic Engineering Problem
    The Metabolic Engineering Problem describes a new optimization approach to identify the optimal metabolic and regulatory gene deletions to maximize the production of a desired chemical. The case study includes an applet for experimentation.
  • Protein Structure Determination
    This case study presents two formulations for the Nuclear Magnetic Resonance (NMR) Structure Based Assignment (SBA) problem for assigning NMR spectrum peaks to underlying atoms.